Laboratory of Molecular Oncology focuses on two major research areas: antitumor gene therapy directed by engineered mesenchymal stromal cells and exploration of the effect of the tumor microenvironment on intratumor heterogenity, cancer stem cells and tumor dormancy.
Particular project are focused on:
- Role of exosomes in stem cell-based cancer gene therapy
- Gene-directed enzyme/prodrug therapy mediated by mesenchymal stromal cells
- Suicide cytotoxicity and bystander effect of yCD/5-FC therapy in human medullary thyroid carcinoma
- Apoptosis-inducing mesenchymal stromal cells in experimental cancer gene therapy
- Role of human mesenchymal stromal cells in tumor microenvironment and drug resistance of tumors
- The role of ALDH1 in chemoresistance of colon cancer cells
- Hunting for the dormant cancer cells
Head of laboratory: Kučerová Lucia
Scientists
- Altaner Čestmír
- Bizik Jozef
- Cihová Marína
- Együdová Katarína
- Kozovská Zuzana
- Kučerová Lucia
- Lakota Ján
- Matúšková Miroslava
- Poturnajová Martina
- Tyčiaková Silvia
- Dubrovčáková Mária
- Lineková Alena
- Schmidtová Silvia
- Toro Lenka
- Školeková Svetlana
- Ďuriníková Erika
- Bohovič Roman
- Buríková Monika
- Demková Lucia